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About CF » Pathophysiology of CF » Airway » Normal airway

Normal airway

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Under normal circumstances, the airway surface liquid (ASL) provides a low-viscosity environment for beating cilia to effectively clear mucus and pathogens from the airways. The composition, volume and osmolality of the ASL is therefore important for normal airway function.1-6

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  1. Rowe SM et al. N Engl J Med 2005;52:1992–2001
  2. Ratjen FA. Respir Care 2009;54:595–605
  3. Boucher RC. Eur Respir J 2004;23:146–58
  4. Boucher RC. Annu Rev Med 2007;58:157–70
  5. Donaldson S et al. Chest 2007;132:1631–6
  6. Goralski JL et al. Curr Opin Pharmacol 2010;10:294–9