Normal function in exocrine pancreas1 of 2 << Back to Pancreas
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CFTR is located in apical membrane of pancreatic duct cells and plays a key role in ductal bicarbonate (HCO3–) secretion, thereby maintaining the appropriate volume and pH of pancreatic secretions.1,2
The normal exocrine pancreas has ducts arranged into clusters that are responsible for producing enzymes to digest lipids and proteins in the duodenum.
CFTR, located in the apical membrane of the pancreatic duct cells, secrete Cl– and HCO3– into the lumen of pancreatic ducts.
This maintains the correct alkaline pH, ensuring that stomach acid is neutralised by pancreatic bicarbonate and that an optimal environment is created for the activity of pancreatic enzymes.
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insufficiency in CF.