Sweat gland<< Back to Pathophysiology of CF
At first glance, it would seem that the sweat glands of CF sufferers do not seem to be abnormal — there are no obstructions to ducts and sweat is readily produced. However, people with CF produce sweat containing elevated amounts of salt.
This hallmark sign is used to reliably diagnose up to 98% of individuals with CF.1 Moreover, evidence suggests that the level of sweat chloride correlates with disease severity. For example, sufferers with ‘mild’ CF tend to have lower sweat chloride levels than those with pancreatic insufficiency.2
Correlation between CFTR activity and CF symptoms. Modified from Mishra et al.1
Sweat chloride levels
Find out how CF modifies sweat chloride levels.