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About CF » Pathophysiology of CF » Sweat gland » How CF modifies sweat chloride levels at the cellular level

How CF modifies sweat chloride levels at the cellular level

The exocrine sweat gland is a tubular-like structure embedded in the dermis and is composed of two main compartments: a secretory coil and reabsorptive duct.

LEFT: Normal sweat is secreted as an isotonic solution of water and sodium chloride into the secretory coil. As the sweat passes along the tubule, sodium chloride (NaCl) is absorbed into reabsorptive duct cells producing a hypotonic bead of sweat.

RIGHT: In CF, the CFTR channel is unable to transport chloride into the duct cells producing sweat with high salt concentration.1

  1. Quinton P. Physiology (Bethesda) 2007;22:212–25