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About CF » Role of CFTR in CF » Pathophysiology of CF » Sweat gland

Sweat gland

At first glance, it would seem that the sweat glands of CF sufferers do not seem to be abnormal — there are no obstructions to ducts and sweat is readily produced. However, people with CF produce sweat containing elevated amounts salt.

This hallmark sign is used to reliably diagnose up to 98%1 of individuals with CF. Moreover, evidence suggests that the level of sweat chloride correlates with disease severity. For example, sufferers with ‘mild’ CF tend to have lower sweat chloride levels than those with pancreatic insufficiency2.

Sweat gland table

Correlation between CFTR activity and CF symptoms. Modified from Mishra et al1.

 

Sweat chloride levels

Find out how CF modifies sweat chloride levels.

Learn more
References
  1. Mishra A et al. The Relevance of Sweat Testing for the Diagnosis of Cystic Fibrosis in the Genomic Era 2005;Clin Biochem Rev. 26:135–153
  2. Farrell PM et al. Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report. J Pediatr. 2008;153:S4-S14.