• is an online educational resource on the genetics of cystic fibrosis (CF) and the role of CF transmembrane conductance regulator (CFTR) in normal human physiology as well as in CF.
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  • All of the information about CFTR and CFTR modulators has been obtained from referenced sources and is in the public domain.
  • This website is not intended to promote or advocate a particular course of treatment or any specific drug, whether licensed or unlicensed, nor is it intended to imply or suggest that any drug be used for any purpose other than that which for which it is licensed in the EU.


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Drug research and development

Drug research and development

Over the last 40 years clinical trials have played a vital role advancing the care of people with cystic fibrosis. More recently, the establishment of international clinical trials networks has served to optimize the development and evaluation of novel treatments for CF throughout Europe and beyond.1 This module highlights ongoing CF clinical trials throughout Europe. For more information on ECFS-Clinical Trial Network, please visit

Explaining drug development

Get a top-level overview of the various stages that comprise clinical trials: from basic research to bringing a drug to market

Pre-clinical development

Discover different approaches to treatment of cystic fibrosis

Clinical trials

This section offers a summary of current clinical trials in Europe that involve CFTR modulators and gene therapy — this information will be updated on a regular basis


1. Döring G. et al. Journal of Cystic Fibrosis. 6:85–99 (2007)